Genetic Architecture of Idiopathic Generalized Epilepsy: Clinical Genetic Analysis of 55 Multiplex Families
نویسندگان
چکیده
منابع مشابه
A clinical study of syndromes of idiopathic (genetic) generalized epilepsy.
OBJECTIVES Epidemiologic data concerning idiopathic generalized epilepsies (IGEs) are scarce or often unreliable. In the current study, we specifically analyzed the syndromes of IGE based on their demographic, clinical, and EEG findings to determine if other than the seizure type(s) and age of onset, there are any other distinctive features to distinguish these syndromes of IGEs from one anothe...
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PURPOSE Ethnic variation in epilepsy classification was reported in the Epilepsy Phenome/Genome Project. This study aimed to determine the ethnic variation in the prevalence of genetic (idiopathic) generalized epilepsy (GGE) and GGE with family history in a multi-ethnic Asian population in Malaysia. METHOD In this cross-sectional study, 392 patients with a clinical diagnosis of GGE were recru...
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implicit and unobserved errors and vulnerabilities issues usually arise in cryptographic protocols and especially in authentication protocols. this may enable an attacker to make serious damages to the desired system, such as having the access to or changing secret documents, interfering in bank transactions, having access to users’ accounts, or may be having the control all over the syste...
15 صفحه اولApplication of Massively Parallel Sequencing to Genetic Diagnosis in Multiplex Families with Idiopathic Sensorineural Hearing Impairment
Despite the clinical utility of genetic diagnosis to address idiopathic sensorineural hearing impairment (SNHI), the current strategy for screening mutations via Sanger sequencing suffers from the limitation that only a limited number of DNA fragments associated with common deafness mutations can be genotyped. Consequently, a definitive genetic diagnosis cannot be achieved in many families with...
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Epilepsy is a disease with substantial missing heritability; despite its high genetic component, genetic association studies have had limited success detecting common variants which influence susceptibility. In this paper, we reassess the role of common variants on epilepsy using extensions of heritability analysis. Our data set consists of 1258 UK patients with epilepsy, of which 958 have foca...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2004
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.0013-9580.2004.46803.x